Triadin Knockout syndrome
New cause of recessive genetic LQTS
- Presents before 5 years of age
- sudden cardiac arrest common
- Beta blockers no use
- ECG show symmetric inversion in anterior leads +/- Qt prolongation
- These may be the genotype negative cases of CPVT
- Triadin links calsequestrin, ryanodine receptor and junctophilin to L type calcium channel in myocardium
- Personal history of VF,VT or therapy of same
- Family history of scd events
- Unexplained syncope
- NSVT of rate more than 120 in holter
- Maximum LV wall thickness more than 30 mm
Ref Gersh et al Acc guideline 2011
Best view to assess SAM is
See comments for answer
A new score to help predict adverse events in patients with frequent premature ventricular contractions (PVCs).
In the study predictors of adverse remodeling were:
- non-sustained VT) (odds ratio [OR], 5.3)
- longer PVC coupling interval of at least 500 ms (OR, 4.7)
- PVC burden (OR, 4.4 for >20%; OR, 3.5 for 10% to 20%)
- Superiorly directed PVC axis (OR, 2.7)
These parameters were scored and scores from 0 to 4 were classified as low risk; from 5 to 8, intermediate risk; and from 9 to 12, high risk.
- Doesn’t include patients with low coupling interval prone for R on T phenomena
- PVC dispersion not included in score
- LV remodelling assessment by EF and correlating with endpoint may not be fool proof
Voskoboinik, Aleksandr et al.Predictors of Adverse Outcome in Patients with Frequent Premature Ventricular Complexes: the ABC-VT Risk Score. Heart Rhythm
Brugada like ST elevation is seen in which short QT syndrome type ?
Most common presenting clinical feature of short QT syndrome is?
- Atrial fibrillation
- Cardiac arrest
- Chest pain
Answer in comment section
What are the differences between in stent restenosis in a bare metal stent vs a drug eluting stent??
- Flecainide toxicity
- Beta blocker excess
- TCA toxicity
- Biventricular pacing
Answer will be posted in comment section soon
By far BAV is the most common congenital heart disease
Angiographically two types of BAV can be identified-Equally bicuspid and unequal
Interestingly Coarctation is associated with an “equally bicuspid ” aortic valve
It may be denoting a different pathogenetic process altogether
Ref :Catheterization and Cardiovascular Diagnosis 10:17-25 (1984)
Incidence of BAV is maximum in which of the following condition?
- Turner syndrome
- Supravalvular AS
- Coarctation of Aorta
Answer will be posted in comment section soon !
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